Categories
Tazobactam acid
- CAS: 89786-04-9
- Purity: 99%
- Export Top Purity Tazobactam acid 89786-04-9 In Stock
Export Top Purity Tazobactam acid 89786-04-9 In Stock
- Molecular Formula: C10H12N4O5S
- Molecular Weight: 300.295
- Appearance/Colour: White or off-white powder
- Vapor Pressure: 5.55E-21mmHg at 25°C
- Melting Point: 115-145℃
- Refractive Index: 1.817
- Boiling Point: 707.1 °C at 760 mmHg
- PKA: 2.33±0.40(Predicted)
- Flash Point: 381.4 °C
- PSA： 127.43000
- Density: 1.92 g/cm3
- LogP: -0.40470
Tazobactam acid(Cas 89786-04-9) Usage
|
Therapeutic Function |
Antibiotic |
|
Antimicrobial activity |
Tazobactam exhibits little useful antimicrobial activity, although weak activity against Acinetobacter spp. and Borrelia burgdorferi has been reported. |
|
Veterinary Drugs and Treatments |
Although veterinary experience is limited with piperacillin or piperacillin/ tazobactam, these drugs have expanded coverage against many bacteria and may be suitable for empiric use until culture and susceptibility data are available, or for surgical prophylaxis when gram-negative or mixed aerobic/anaerobic infections are concerns. |
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Drug interactions |
Potentially hazardous interactions with other drugs Reduced excretion of methotrexate - monitor methotrexate levels during concomitant treatment. Enhanced action of vecuronium and similar neuromuscular blocking agents. |
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Metabolism |
Piperacillin is metabolised to a minor microbiologically active desethyl metabolite. Tazobactam is metabolised to a single metabolite that has been found to be microbiologically inactive. Piperacillin and tazobactam are eliminated via the kidney by glomerular filtration and tubular secretion. Piperacillin, tazobactam, and desethyl piperacillin are also secreted into the bile. |
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Definition |
ChEBI: A member of the class of penicillanic acids that is sulbactam in which one of the exocyclic methyl hydrogens is replaced by a 1,2,3-triazol-1-yl group; used (in the form of its sodium salt) in combination with ceftolozane sulfate for treatment of complicat d intra-abdominal infections and complicated urinary tract infections. |
InChI:InChI=1/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1
89786-04-9 Relevant articles
2 β - Azidomethyl penicillanic acid dibenzoate. Preparation method of tazobactam intermediate and tazobactam
-
, (2021/11/21)
The invention provides a preparation met...
Application of Continuous Flow in Tazobactam Synthesis
Sun, Tiemin,Wang, Jiasheng,Wu, Chengjun,Xin, Yunting,Zhou, Shuhao
, p. 1648 - 1657 (2021/07/19)
Tazobactam is a β-lactamase inhibitor. I...
2 β -triazole methylpenicillanic acid dibenzoate. Preparation method of tazobactam intermediate and tazobactam
-
, (2021/11/21)
The invention provides a preparation met...
Tazobactam intermediate, preparation method thereof and method for preparing tazobactam by using intermediate (by machine translation)
-
Paragraph 0097-0102, (2020/11/23)
The intermediate V is prepared from glyo...
89786-04-9 Process route
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-
tazobactam 3,5-dinitrobenzyl ester
-
-
89786-04-9,115546-66-2,124995-08-0
tazobactam acid
| Conditions | Yield |
|---|---|
|
With
palladium on activated charcoal; hydrogen;
In
dichloromethane;
at 20 - 30 ℃;
Temperature;
|
94.2%
|
-
-
tazobactam benzyl ester
-
-
89786-04-9,115546-66-2,124995-08-0
tazobactam acid
| Conditions | Yield |
|---|---|
|
With
palladium on activated charcoal; hydrogen;
In
ethanol;
for 1.5h;
under 375.038 Torr;
|
96.19%
|
89786-04-9 Upstream products
-
24138-28-1
6-bromopenicillanic acid
-
551-16-6
6-Aminopenicillanic Acid
-
122661-93-2
2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penicillin-3α-carboxylic acid diphenylmethyl ester
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85573-72-4
(R)-2-[2-(benzothiazol-2-yldisulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyl-3-enoic acid benzhydryl ester
89786-04-9 Downstream products
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59703-84-3
sodium piperacillin
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89785-84-2
tazobactam sodium
