Categories
Sitagliptin phosphate
- CAS: 654671-78-0
- Purity: 99%
- Buy cost-effective 99% pure Sitagliptin phosphate 654671-78-0 now
Quality products?make an important contribution to long-term revenue and profitability. Buy cost-effective 99% pure Sitagliptin phosphate 654671-78-0 now
1.What is the Sitagliptin phosphate ?
Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.
-
![(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate](/upload/2026/8/d8e338b8e6c64e7f98a7a7d4e82e1177_22cea329-dfcf-43b7-856d-9237c01f238a.png)
-
486460-23-5
(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate
-
-
654671-78-0,790712-60-6
sitagliptin phosphate
| Conditions | Yield |
|---|---|
|
(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate;
With
hydrogenchloride;
In
methanol;
With
phosphoric acid;
|
91% |
|
(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate;
With
hydrogenchloride;
In
dichloromethane; water;
at 0 - 30 ℃;
for 2h;
With
phosphoric acid; sodium hydroxide;
In
water;
at 70 - 75 ℃;
|
86.2% |
|
(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate;
With
hydrogenchloride;
In
water; isopropyl alcohol;
at 20 - 55 ℃;
for 5h;
With
phosphoric acid;
In
propan-1-ol; water;
at 60 - 65 ℃;
|
0.725 g |
|
(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate;
With
hydrogenchloride; acetic acid;
In
water;
for 3h;
Reflux;
With
phosphoric acid;
In
ethanol; water;
at 20 - 80 ℃;
for 20h;
|
|
|
Multi-step reaction with 2 steps
1: hydrogenchloride / water; methanol
2: phosphoric acid / water; ethanol / 20 h / 20 - 80 °C
With
hydrogenchloride; phosphoric acid;
In
methanol; ethanol; water;
|
|
|
Multi-step reaction with 2 steps
1: water; hydrogenchloride / methanol / 4 h / 20 °C
2: phosphoric acid / ethanol / 0.5 h / 80 °C
With
hydrogenchloride; phosphoric acid; water;
In
methanol; ethanol;
|
|
|
(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate;
With
hydrogenchloride;
In
isopropyl alcohol;
at 20 - 25 ℃;
With
phosphoric acid;
In
Isopropyl acetate; water; isopropyl alcohol;
at 20 - 77 ℃;
for 2.5h;
|
|
|
Multi-step reaction with 2 steps
1: hydrogenchloride / 1 h
2: phosphoric acid; water / isopropyl alcohol / 70 - 80 °C
With
hydrogenchloride; phosphoric acid; water;
In
isopropyl alcohol;
|
-
![3(R)-3-[(benzyloxy)amino]-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one](/upload/2026/8/9edbca4f0d114d31932bdc38c1ed0208_854fe0c8-9d58-4123-b091-d745d5234e81.png)
-
1361389-75-4
3(R)-3-[(benzyloxy)amino]-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
654671-78-0,790712-60-6
sitagliptin phosphate
| Conditions | Yield |
|---|---|
|
3(R)-3-[(benzyloxy)amino]-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;
With
ammonium formate;
In
methanol;
at 65 ℃;
for 2h;
Inert atmosphere;
With
phosphoric acid;
In
water;
at 50 - 70 ℃;
for 1.5h;
|
89% |
|
3(R)-3-[(benzyloxy)amino]-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;
With
palladium 10% on activated carbon; hydrogen; benzyl chloride;
In
ethanol; water;
at 40 ℃;
under 2068.65 Torr;
Autoclave;
Inert atmosphere;
With
phosphoric acid;
In
ethanol; water;
at 75 ℃;
Reagent/catalyst;
Temperature;
|
63% |
|
With
phosphoric acid;
In
isopropyl alcohol;
at 30 ℃;
for 16h;
Solvent;
|
0.75 g |
|
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / water; ethanol / 50 °C / 2068.65 Torr / Large scale
2: phosphoric acid / water; ethanol / 50 - 74 °C / Large scale
With
phosphoric acid; palladium 10% on activated carbon; hydrogen;
In
ethanol; water;
|
2.What is the CAS number for Sitagliptin phosphate ?
The CAS number of Sitagliptin phosphate is 654671-78-0.
More information of Sitagliptin phosphate 654671-78-0 are:
|
CAS?Number |
654671-78-0 |
|
Melting Point |
202-204 °C |
|
Boiling Point |
529.9 °C at 760 mmHg |
|
Flash Point |
274.3 °C |
|
Vapor Pressure |
2.59E-11mmHg at 25°C |
|
HS CODE |
2933990090 |
|
PSA |
164.61000 |
|
LogP |
1.72610 |
3.What are another words for Sitagliptin phosphate ?
Synonyms?for?Sitagliptin phosphate 654671-78-0:(2R)-4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate salt;MK 0431;
4.What is the molecular formula of Sitagliptin phosphate?
The chemical formula of ?Sitagliptin phosphate is?C16H18F6N5O5P which containing 16 Carbon atoms,18 Hydrogen atoms,6 Fluorine atoms,5 Nitrogen atoms,5 Oxygen atoms and 1 Phosphorus atoms,and the molecular weight of??Sitagliptin phosphate?is 505.31.
5.What is Sitagliptin phosphate (654671-78-0) used for?
Sitagliptin is the first novel dipeptidyl peptidase IV inhibitor from Merck for the treatment of type 2 diabetes without weight gain and the incidence of hypoglycemia was similar to placebo. Sitagliptin acts by enhancing the body’s incretin system, which helps to regulate glucose by affecting β and α cells in the pancreas.
InChI:InChI=1/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)/t9-;/m1./s1
Relevant articles related to Sitagliptin phosphate:
|
Article |
Source |
|
Preparation method of sitagliptin phosphate monohydrate crystal form |
- Paragraph 0022-0057, (2021/05/05) |
|
Synthesis of (?)-(R)-Sitagliptin by RhI-Catalyzed Asymmetric Hydroamination |
Berthold, Dino,Breit, Bernhard supporting information, p. 6247 - 6249 (2021/09/25) |
6.Buy Sitagliptin phosphate with the best price .
qingdao feisite trading co,.ltd is a quality supplier of Sitagliptin phosphate. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Sitagliptin phosphate 654671-78-0.
